What is the main symptom of febrile non-hemolytic transfusion reactions?

• A. Severe hypotension
• B. Fever without hemolysis
• C. Flank pain
• D. Anaphylactic shock

Answer: (B)

The main symptom of febrile non-hemolytic transfusion reactions is fever without hemolysis. This type of reaction is characterized by an increase in body temperature, typically more than 1 degree Celsius, that occurs during or shortly after a blood transfusion. It is primarily an immune response to donor white blood cells or other components present in the transfused blood. The lack of hemolysis differentiates this reaction from others that involve the destruction of red blood cells, including hemolytic transfusion reactions.

The development of a fever in these cases is usually accompanied by chills and discomfort, which highlights the body's immune response rather than a severe systemic reaction that might be seen with other types of transfusion reactions. Understanding this symptom is crucial for identifying and managing febrile non-hemolytic reactions in a clinical setting.