What is the expected effect of glucagonoma on skin conditions?

• A. Development of dermatitis
• B. Necrolytic migratory erythema
• C. Hyperpigmentation
• D. Hair loss

Answer: (B)

Glucagonoma is a rare pancreatic neuroendocrine tumor that secretes an excess of glucagon. One of the hallmark skin conditions associated with glucagonoma is necrolytic migratory erythema. This condition presents as erythematous, blistering and crusting lesions that can occur on the groin, buttocks, and other areas of the body. The lesions are often described as migrating and can be painful and pruritic.

The presence of necrolytic migratory erythema is linked to the hyperglycemic effects of glucagon, which leads to an increase in the metabolism of amino acids and may result in a deficiency of essential fatty acids, contributing to the characteristic skin findings. Recognizing necrolytic migratory erythema in patients with suspected glucagonoma can lead to early diagnosis and management of this malignancy, making it an essential concept in understanding the systemic effects of glucagon-secreting tumors.