What is the association of meconium ileus?

• A. Celiac disease
• B. Down syndrome
• C. Cystic fibrosis
• D. Intestinal atresia

Answer: (C)

Meconium ileus is primarily associated with cystic fibrosis, a genetic disorder that affects the respiratory and digestive systems. In cystic fibrosis, the production of thick and sticky mucus leads to obstructions in various parts of the body. When meconium, which is the first stool of a newborn, becomes abnormally thick due to the effects of cystic fibrosis, it can result in a blockage in the intestines, specifically causing meconium ileus. This is commonly one of the first signs of cystic fibrosis in newborns and can necessitate surgical intervention to relieve the obstruction.

Other conditions like celiac disease and intestinal atresia do not typically present as meconium ileus. While Down syndrome has various associations, meconium ileus is not specifically linked to it in the same way as cystic fibrosis. Thus, the connection between meconium ileus and cystic fibrosis is crucial for understanding both the diagnosis and management of the condition in affected infants.